Bacterial biofilms and the pathophysiology of chronic rhinosinusitis.
نویسندگان
چکیده
PURPOSE OF REVIEW To review the evidence for the presence of bacterial biofilms in chronic rhinosinusitis (CRS) and mechanisms by which they may contribute to the chronic inflammation characteristic of this disease. Lastly, to provide an overview of the current and potential future treatments for bacterial biofilms in CRS. RECENT FINDINGS Advances in the techniques for identifying biofilms have confirmed the presence of bacterial biofilms on the sinonasal mucosa of patients with CRS. The impact on mucosal inflammation of the polymicrobial or multiorganism milieu is not yet well understood. Numerous novel topical therapies for the treatment of bacterial biofilms in CRS have been suggested with some demonstrating clinical efficacy. Blocking of quorum sensing represents a potential future therapy for biofilm treatment in CRS and biofilm infection at large. SUMMARY Biofilms represent an important influence on the pathophysiology of CRS. Further understanding of biofilm interactions and microbial organism behavior will provide us with future treatment modalities for this disease.
منابع مشابه
Biofilm in chronic sinusitis with nasal polyps: pilot study.
UNLABELLED Chronic rhinosinusitis' pathogenesis is not completely established and there are some explanations for this disease, such as osteitis, superantigens, fungal-mediated hypersensitivity and, more recently, biofilms. There are no reports in Portuguese about biofilms in chronic rhinosinusitis. AIM To reproduce a method for visualization of biofilms in patients with chronic rhinosinusiti...
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1 Craven DE, Chroneou A, Zias N, et al. Ventilator-associated tracheobronchitis: the impact of targeted antibiotic therapy on patient outcomes. Chest 2009; 135:521–528 2 Paju S, Scannapieco FA. Oral biofilms, perodontitis, and pulmonary infections. Oral Dis 2007; 13:508–512 3 Prince AA, Steiger JD, Khalid AN, et al. Prevalence of biofilms-forming bacteria in chronic rhinosinusitis. Am J Rhinol ...
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Background There is increasing evidence that biofilms are critical to the pathophysiology of chronic infections including chronic rhinosinusitis (CRS). Until relatively recently, our understanding of biofilms was limited. Recent advances in methods for biofilm identification and molecular biology have offered new insights into the role of biofilms in CRS. With these insights, investigators have...
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ورودعنوان ژورنال:
- Current allergy and asthma reports
دوره 8 3 شماره
صفحات -
تاریخ انتشار 2008